Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2013; 19(48): 9256-9270
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9256
Table 3 Substances and hepatic intoxication mechanisms contrasted by curcumin
IntoxicationsPathogenetic mechanismsCurcumin effects
Iron (alcoholic liver disease; steatosis, viral hepatitis; anemia)Fibrosis induced by oxidationAnti-oxidant enzymatic activity
Alcohol (chronic or acute intoxication)Phospholipase A2 activationPhospholipase A2 inhibition by NF-κB
High-fat diet (lipid storage)Focal degeneration, micronecrosisAcil-CoA, cholesterol biliary acids; LDL peroxidation
Xenobiotics induced acute damageROS, lipid peroxidation, inflammationScavenger activity on NF-κB; anti-oxidant enzymatic activity
Xenobiotics induced chronic damageInflammation and hepatocellular necrosisHepatic fibrosis inhibition by NF-κB
Poisons (carbon tetrachloride)Inflammatory self-maintenanceHepatic inflammation inhibition by NF-κB