Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9256
Revised: September 10, 2013
Accepted: September 15, 2013
Published online: December 28, 2013
Core tip: Curcumin is a well-established molecule with multiple pharmacological activities, mainly anti-inflammatory and anti-proliferative. The major hurdle for a widespread clinical use has been represented by its poor bioavailability, which has been recently overcome by the development of a new formulation combining curcumin with phospholipids (curcumin-phytosome). This compound permits to improve markedly intestinal absorption of curcumin and guarantees a greater tissue delivery than the traditional curcuminoid mixtures. So, curcumin-phythosome has the potential to be exploited in many gastrointestinal diseases, both functional and organic.