Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 21, 2013; 19(47): 9092-9103
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9092
Figure 2
Figure 2 Apparent diffusion coefficient maps for tumors. A: Representative maps of apparent diffusion coefficient (ADC)all and ADChigh for liver tumors (solid arrow) in three groups. The area of therapy-induced necrosis (dotted arrow) was significantly larger in the ZDTHA group than those observed in both the ZD6126 and control groups; B: The dynamic change of ADCall during the experiment (aP < 0.05, bP < 0.01 vs control; respectively); C: The dynamic change of ADChigh during the experiment. Compared to the ADCall, the increased diffusion due to therapeutic necrosis was better reflected with ADChigh in both the ZDTHA and ZD6126 groups on day 2 (bP < 0.01 vs control; cP < 0.05 vs ZD6126); D: Representative maps of ADClow and ADCperf for liver tumors (arrow) in the three groups. The signal intensities observed on ADClow maps were always higher than those observed on ADCperf maps at each time point in each group, because ADClow combines both the perfusion and diffusion effects; E: The dynamic change of ADClow during the experiment (aP < 0.05 vs control; cP < 0.05 vs ZD6126); F: The dynamic change of ADCperf during the experiment. Compared to the ADClow, the perfusion reduction due to the shutdown of tumor vessels was better reflected with ADCperf in both the ZDTHA and ZD6126 groups at 4 h (aP < 0.05 vs control). Furthermore, the ADCperf in the ZDTHA group was even lower compared to the ZD6126 group at 4 h (cP < 0.05 vs ZD6126).