Editorial Open Access
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. Mar 21, 2010; 16(11): 1303-1303
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1303
Alcohol and liver, 2010
Natalia A Osna, Liver Study Unit, Research Service (151), VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, United States
Author contributions: Osna NA, a series editor of Topic Highlight “Alcohol and liver, 2010” wrote this Introduction.
Correspondence to: Natalia A Osna, MD, PhD, Liver Study Unit, Research Service (151), VA Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, United States. nosna@unmc.edu
Telephone: +1-402-9953735 Fax: +1-402-4490604
Received: January 20, 2010
Revised: March 8, 2010
Accepted: March 15, 2010
Published online: March 21, 2010


Liver is known as an organ that is primarily affected by alcohol. Alcoholic liver disease (ALD) is the cause of an increased morbidity and mortality worldwide. Progression of ALD is driven by “second hits”. These second hits include the complex of nutritional, pharmacological, genetic and viral factors, which aggravate liver pathology. However, in addition to liver failure, ethanol causes damage to other organs and systems. These extrahepatic manifestations are regulated via the similar hepatitis mechanisms. In the Topic Highlight series, we provide an update of current knowledge in the field of ALD.

Key Words: Liver, Alcohol

Our Topic Highlight: “Alcohol and liver" is annually published in World Journal of Gastroenterology and reviews the most important discoveries in the field of alcoholic liver disease (ALD). In the current third edition of “Alcohol and liver", we focus on the ethanol-induced cross-talk between the liver and other alcohol-affected organs, such as gut, brain and pancreas[1-3]. Also, signal transduction aspects of ALD include the role of an adiponectin/interleukin-10/heme oxygenase-1 pathway[4], the impact of alcohol on hepatitis C virus replication and interferon signaling[5] and the role of Toll-like receptor signaling[6]. In addition, certain reviews published in this issue shed light on molecular mechanisms of liver cell damage, as well as other aspects of ALD pathogenesis, such as the effects of ethanol on proteasome-interacting proteins[7], alterations of hepatocyte cytoskeleton[8], hepatoprotective effect of S-adenosyl-L-methionine against alcohol in CYP2E1-dependent liver injury[9] and gender/hormonal differences in ALD development[10]. We believe that this issue will be of strong interest not only for gastroenterologists, but also for those involved in alcohol, liver and brain research.


S- Editor Tian L L- Editor Wang XL E- Editor Zheng XM

1.  Wang HJ, Zakhari S, Jung MK. Alcohol, inflammatio. n, and gut-liver-brain interactions in tissue damage and disease development. World J Gastroenterol. 2010;16:1304-1313.  [PubMed]  [DOI]  [Cited in This Article: ]
2.  Clemens DL, Mahan KJ. Alcoholic pancreatit. is: Lessons from the liver. World J Gastroenterol. 2010;16:1314-1320.  [PubMed]  [DOI]  [Cited in This Article: ]
3.  Szabo G, Bala S. Alcoholic liver dise. ase and the gut-liver axis. World J Gastroenterol. 2010;16:1321-1329.  [PubMed]  [DOI]  [Cited in This Article: ]
4.  Mandal P, Pritchard MT, Nagy LE. Anti-inflammatory pa. thways and alcoholic liver disease: Role of an adiponectin/interleukin-10/heme oxygenase-1 pathway. World J Gastroenterol. 2010;16:1330-1336.  [PubMed]  [DOI]  [Cited in This Article: ]
5.  McCartney EM, Beard MR. Impact of alcohol on. hepatitis C virus replication and interferon signaling. World J Gastroenterol. 2010;16:1337-1343.  [PubMed]  [DOI]  [Cited in This Article: ]
6.  French SW, Oliva J, French BA, Li J, Bardag-Gorce F. Alcohol, nutrition a. nd liver cancer: Role of Toll-like receptor signaling. World J Gastroenterol. 2010;16:1344-1348.  [PubMed]  [DOI]  [Cited in This Article: ]
7.  Bardag-Gorce F. Effects of ethanol o. n the proteasome interacting proteins. World J Gastroenterol. 2010;16:1349-1357.  [PubMed]  [DOI]  [Cited in This Article: ]
8.  Shepard BD, Tuma PL. Alcohol-induced alte. rations of the hepatocyte cytoskeleton. World J Gastroenterol. 2010;16:1358-1365.  [PubMed]  [DOI]  [Cited in This Article: ]
9.  Cederbaum AI. Hepatoprotective eff. ects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World J Gastroenterol. 2010;16:1366-1376.  [PubMed]  [DOI]  [Cited in This Article: ]
10.  Eagon PK. Alcoholic liver inju. ry: Influence of gender and hormones. World J Gastroenterol. 2010;16:1377-1384.  [PubMed]  [DOI]  [Cited in This Article: ]