Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation

Figure 1 Histology of liver grafts. (A) Diffuse mono nuclear cell infiltration, massive necrosis and interstitial hemorrhage; (B) Cel lular infiltration obviously decreased, but severe hepatocyte necrosis and hemor rhage unchanged; (C) Splenectomy significantly alleviated hepatocyte necrosis and hemorrhage, but didnot change diffus mononuclear cell infiltration; (D) The architecture of the hepatic lobule was preserved, but there was slight cellular in filtration in the portal tracts.

Figure 2 Expression of perforin and granzyme B genes in liver xenografts on POD 7. A. Perforin; B. Granzyme B.