Endotoxins enhance hepatocarcinogenesis induced by oral intake of thioacetamide in rats

Figure 1 Section of liver from an untreated control (sham) rat. HE × 20.

Figure 2 Section of liver from a TAA control rat treated as described in Materials and Methods. The nodules show the transforming hepatocytes and the hepatocarcinoma. The spindle fibroblasts are recognized around such hyperplastic nodules. HE × 20.

Figure 3 Section of liver from a rat in TAA + ST group. Pseudoglandular structures and spindle cells are observed in perivenular areas. HE × 20.

Figure 4 Section of liver from a rat in TAA + ST + LPS group. The disorganized and atypical hepatocytes formed a “mucoid lake” with floating of small cells. HE × 20.

Figure 5 Ultrastructure of hepatocellular carcinoma from a rat in TAA + ST + LPS group. Uranyl acetate and lead citrate staining × 400.

Figure 6 Ultrastructure of cirrhosis from a rat in TAA + ST + LPS group. The bundles of collagen fibrils were present with atypical hepatocytes. Uranyl acetate and lead citrate staining × 800.