Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

Figure 1 Follow-up of liver fibrosis in liver transplanted patients in the presence or absence of the E2 and E4 allele. A: METAVIR (F0F1) in the presence or absence of the E2 allele; B: METAVIR (F0F1) in the presence or absence of the E4 allele; C: METAVIR (F2) in the presence or absence of the E2 allele; D: METAVIR (F2) in the presence or absence of the E4 allele; E: METAVIR (F3F4) in the presence or absence of the E2 allele; F: METAVIR (F3F4) in the presence or absence of the E4 allele. ^aP < 0.01. E2- and E4-: Absence of the respective alleles; E2+ and E4+: Presence of the respective alleles. Fisher chi-square test; F: Degree of fibrosis; NA: Not applicable.

Figure 2 Follow-up using non-invasive methods (aspartate aminotransferase to platelet ratio index and fibrosis 4) of liver transplant patients in the presence or absence of the E2 and E4 alleles. A: Post-orthotopic liver transplantation (OLT) apolipoprotein E gene (APOE) curve for mean aspartate aminotransferase to platelet ratio index (APRI) and fibrosis 4 (FIB4); B: Post-OLT curve considering the presence or absence of APOE2 for mean APRI; C: Post-OLT curve considering the presence or absence of APOE4 for mean APRI; D: Post-OLT curve considering the presence or absence of APOE2 for mean FIB4; E: Post-OLT curve considering the presence or absence of APOE4 for mean FIB4. Two-way ANOVA, results are shown in mean ± SEM. ^aP < 0.01. ^bP < 0.01. E2- and E4-: Absence of the respective alleles; E2+ and E4+: Presence of the respective alleles. APOE: Apolipoprotein E gene; OLT: Orthotopic liver transplantation; APRI: Aspartate aminotransferase to platelet ratio index; FIB4: Fibrosis 4.