Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery

Figure 1 Postoperative time to recovery of liver function to recovery in this cohort. Time to recovery was defined as return to Child-Pugh class A and return of serum total bilirubin and albumin levels to < 2 mg/dL and > 2.8 mg/dL, respectively. It was compared between patients with serum preoperative type IV collagen 7S > 6 ng/mL (n = 70) and those with serum preoperative type IV collagen 7S ≤ 6 ng/mL (n = 145). The time to recovery was significantly shorter in patients with type IV collagen 7S ≤ 6 ng/mL (all, P < 0.001; log-rank test). TB: Total bilirubin; Alb: Albumin.

Figure 2 Postoperative time to recovery of liver function in patients without hepatitis viruses in our study. Time to recovery was defined as return to Child-Pugh class A and return of serum total bilirubin and albumin levels to < 2 mg/dL and > 2.8 mg/dL, respectively. It was compared between patients with serum preoperative type IV collagen 7S > 6 ng/mL (n = 51) and those with serum preoperative type IV collagen 7S ≤ 6 ng/mL (n = 107). The time to recovery was significantly shorter in patients with type IV collagen 7S level ≤ 6 ng/mL (all, P < 0.001; log-rank test). TB: Total bilirubin; Alb: Albumin.

Figure 3 Postoperative time to recovery of liver function in patients who had jaundice preoperatively in our study. Time to recovery was defined as return to Child-Pugh class A and return of serum total bilirubin and albumin levels to < 2 mg/dL and > 2.8 mg/dL, respectively. It was compared between patients with serum preoperative type IV collagen 7S > 6 ng/mL (n = 16) and those with serum preoperative type IV collagen 7S ≤ 6 ng/mL (n = 5). For the long-term postoperative recovery of liver function as well, the time to recovery was significantly shorter in the group with preoperative type IV collagen 7S ≤ 6 ng/mL than in the group with preoperative type IV collagen 7S > 6 ng/mL. The time to recovery of Alb tended to be shorter in the group with preoperative type IV collagen 7S ≤6 ng/mL than in the group with preoperative type IV collagen > 6 ng/mL; however, the difference was not statistically significant. TB: Total bilirubin; Alb: Albumin.

Figure 4 Correlation between (A) collagen and (B) elastin concentrations and post-hepatectomy liver failure in this cohort. Circles indicate patients without post-hepatectomy liver failure, whereas squares indicate patients with post-hepatectomy liver failure. PHLF: Post-hepatectomy liver failure; NPHLF: Non-post-hepatectomy liver failure.