Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma

Figure 1 Immunohistochemical analysis of doublecortin and CaM kinase-like-1 expression. A: Positive expression; B: Negative expression. DCLK1: Doublecortin and CaM kinase-like-1.

Figure 2 Immunohistochemical analysis of doublecortin and CaM kinase-like-1 expression, and epithelial mesenchymal transition and stem cell markers in pancreatic cancer. All pictures show positive expression for each marker (× 200). A: Snail; B: Vimentin; C: E-cadherin; D: N-cadherin; E: CD24; F: CD44; G: CD133; H: EpCAM. DCLK1: Doublecortin and CaM kinase-like-1; EpCAM: Epithelial cell adhesion molecule.

Figure 3 Overall survival of patients according to doublecortin and CaM kinase-like-1 expression. A: The MST of patients with DCLK1-positive tumors was 18.7 mo; B: That of patients with DLCK1-negative tumors was 49.5 mo. The MST of patients with DCLK1 positivity was significantly shorter than that of patients with DCLK1 negativity (P < 0.0001). DCLK1: Doublecortin and CaM kinase-like-1; MST: Median overall survival time.

Figure 4 Relapse-free survival of patients according to doublecortin and CaM kinase-like-1 expression, excluding patients with macroscopic residual tumor. A: RFS of patients with DCLK1 positivity was 10.2 mo; B: That of patients with DCLK1 negativity was 25.5 mo. Relapse of patients with DCLK1 positivity was significantly shorter than that of patients with DCLK1 negativity (P = 0.0005). DCLK1: Doublecortin and CaM kinase-like-1; RFS: Relapse-free survival.