Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease

Figure 1 Immune responses towards the different peptides of (A) the 75 patients and (B) the 20 healthy controls. Patient samples are arranged along the X-axis, FSP antigens along the Y-axis. Squares represent normalized mean counts of interferon-γ-secreting T cells after subtraction of background and standard errors of peptide-specific counts and no peptide control counts. Open boxes: Adjusted T-cell count 0; Shaded boxes: Adjusted T-cell count 0 to 2.5; Solid boxes: Adjusted T-cell count > 2.5.

Figure 2 Influence on frameshift-peptides-specific T cell reactivity of: (A) azathioprine treatment and (B) duration of disease.

Figure 3 Repeated measurements of immune responses of 4 patients. Patient samples are arranged along the X-axis, FSP antigens along the Y-axis. Squares represent normalized mean counts of interferon-γ-secreting T cells after subtraction of background and standard errors of peptide-specific counts and no peptide control counts. Open boxes: Adjusted T-cell count 0; Shaded boxes: Adjusted T-cell count 0 to 2.5; Solid boxes: Adjusted T-cell count > 2.5.