Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients

Figure 1 MiR-133a expression is downregulated in colorectal cancer patients. A: MiR-133a expression was determined by quantitative real-time polymerase chain reaction and normalized against U6 RNA (an endogenous control). Expression was compared between 169 pairs of colorectal cancer tissues (T) and adjacent non-tumorous tissues (N); B: Fold changes of miR-133a of individually matched samples. Data are represented as log₂ fold change (T/N) (< -1, under-expression; -1, unchanged; > 1, over-expression).

Figure 2 Kaplan-Meier curves for overall-survival in 169 colorectal cancer patients. A: MiR-133a level; B: Local invasion; C: Lymph node metastasis; D: Tumor-node-metastasis stage (TNM).