Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11340
Revised: February 24, 2014
Accepted: May 23, 2014
Published online: August 28, 2014
Core tip: In the present study, the level of microRNA-133a (miR-133a) was found to be downregulated in colorectal cancer (CRC) tissues. The altered expression of miR-133a was significantly associated with malignant behavior, including tumor cell differentiation, local invasion, lymph node metastasis and tumor-node-metastasis stage. Multivariate analysis suggested that low expression of miR-133a is an independent prognostic factor for CRC. Furthermore, the data suggest that miR-133a may play a critical role in CRC progression, and thus may serve as a potential therapeutic target.