Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance

Figure 1 β-catenin expression in biopsy specimens and resected tumor tissues (× 200). A: Nuclear β-catenin was overexpressed in biopsy specimens from patients who exhibited resistance to preoperative radiotherapy; B: β-catenin presented mostly in a membrane-associated staining pattern in biopsy specimens from patients who exhibited hyper-radiosensitivity; C: Nuclear β-catenin was overexpressed in specimens with poor tumor regression grading (TRG) (≤ 2); D: β-catenin presented mostly in a membrane-associated staining pattern in specimens with good TRG (≥ 3).