Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 14, 2013; 19(26): 4119-4126
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4119
Figure 1
Figure 1 Toll-like receptors 9-mediated cytokine release in the colonic mucosa. Binding DNA fragments by toll-like receptors (TLRs) of plasmacytoid dendritic cells (pDCs) results in pro-inflammatory cytokine release and subsequent B cell activation together with both CD80 overexpression and B cell proliferation. CD80 provides a costimulatory signal necessary for T cell activation and survival. IFN: Interferon; TNF: Tumor necrosis factor; IL: Interleukin.