Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4119
Revised: April 23, 2013
Accepted: April 28, 2013
Published online: July 14, 2013
Core tip: Toll-like receptor 9 mediated signaling influences and regulates the severity of mucosal inflammation, and seems to have a protective role against malignant transformation. The modulation of toll-like receptor 9 signaling by synthetic oligodeoxynucleotide agonists or antagonists seems to have beneficial therapeutic effect in inflammatory and cancerous colonic disorders.