Dipeptidyl peptidase-4: A key player in chronic liver disease

doi:10.3748/wjg.v19.i15.2298

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2013; 19(15): 2298-2306
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2298

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Figure 1 Pleiotropic effects of dipeptidyl peptidase-4. Dipeptidyl peptidase-4 (DPP-4) exerts various effects on metabolism and chemokine through peptidase activity. In addition, DPP-4 is involved in immune stimulation, binding to and degradation of extracellular matrix, and resistant to anti-cancer agents. DPP-4 also directly affects lipid accumulation. GLP: Glucagon-like peptide; ECM: Extracellular matrix; MMPs: Metalloproteinases; IL: Interleukin; IFN: Interferon; PPAR: Peroxisome proliferator-activated receptor; SREBP: Sterol regulatory element binding protein.

Citation: Itou M, Kawaguchi T, Taniguchi E, Sata M. Dipeptidyl peptidase-4: A key player in chronic liver disease. World J Gastroenterol 2013; 19(15): 2298-2306
URL: https://www.wjgnet.com/1007-9327/full/v19/i15/2298.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i15.2298