Dipeptidyl peptidase-4: A key player in chronic liver disease

doi:10.3748/wjg.v19.i15.2298

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Apr 21, 2013; 19(15): 2298-2306
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2298

Dipeptidyl peptidase-4: A key player in chronic liver disease

Minoru Itou, Takumi Kawaguchi, Eitaro Taniguchi, Michio Sata

Minoru Itou, Eitaro Taniguchi, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan

Takumi Kawaguchi, Michio Sata, Division of Gastroenterology, Department of Medicine and Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume 830-0011, Japan

Author contributions: Itou M and Kawaguchi T collected the materials and wrote the manuscript; Taniguchi E discussed the topic; Sata M supervised the manuscript.

Correspondence to: Takumi Kawaguchi, MD, PhD, Division of Gastroenterology, Department of Medicine and Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. takumi@med.kurume-u.ac.jp

Telephone: +81-942-317902 Fax: +81-942-317820

Received: October 29, 2012
Revised: February 27, 2013
Accepted: March 6, 2013
Published online: April 21, 2013

Core Tip

Core tip: Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor.