Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis

Figure 1 Effect of anti-HMGB1 antibody on the morphology of pancreas and lung in mouse severe acute pancreatitis (SAP). Tissue samples were obtained 12 h after induction of closed duodenal loop pancreatitis. A: HE staining of pancreas (× 200); B: HE staining of lung (× 200).

Figure 2 Effect of anti-HMGB1 antibody on the bacterial translocation to pancreas in mouse severe acute pancreatitis (SAP). Bacterial culture of pancreas was examined 12 h after induction of SAP. A: Positive rate of bacterial culture of pancreas (overall). ^aP < 0.05 vs Sham group; ^cP < 0.05 vs SAP group; B: Positive rate of bacterial culture of pancreas (Gram-positive and Gram-negative bacteria).