Presence of CCK-A, B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary cancer cell lines

Figure 1 Effects of gastrin and CCK on SNU-308 from gallbladder cancer (A), SNU-478 from ampulla of Vater cancer (B). ^aP<0.05 vs control.

Figure 2 Growth curves for SNU-308 (A), and SNU-478 (B, C) cells grown with either hormone or hormone combined with antagonist or antagonist, or medium only. G: gastrin-17, G*: antagonist for CCK-B/gastrin receptor (L-365,260), C: CCK-8, C*: antagonist for CCK-A receptor (L-364,718).

Figure 3 Amplification of CCK-A and CCK-B receptor mRNA in human biliary tract cancer cell lines (A) and pancreatic cancer cell lines (B) by RT-PCR.

Figure 4 Representative slot blot hybridization. (A) Data from SNU-308, 478, 1079, 410, Mia PaCa-2, and LoVo cell lines. (B, C) Densitometrically quantified slot blots.