Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice

Figure 1 Histopathologic changes of forestomachs according to each treatment in BaP-induced forestomach carcinogenesis (n = 5/each group). Note the significantly reduced hyperplasia of the gastric mucosa in PGW8 group, compared with SW groups. A: CO group (normal mucosa of forestomach); B: SW4 group; C: SW8 group; D: PGW4 group; E: PGW8 group (×200).

Figure 2 p53 mRNA expression in BaP-induced forestomach carcinogenesis by RT-PCR analysis (n = 5/each group). The p53 gene expression was greatly down-regulated in PGW8 group, compared to the SW groups. The b-actin transcript levels among all groups were the same. A: CO group, B: SW4 group, C: SW8 group, D: PGW4 group, E: PGW8 group.