Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression

Figure 1 No difference between the effects of omeprazole and esomeprazole on cell turnover of gastric mucosa.

Figure 2 Greatest density of PCNA positive cells (brown colored cells) found in neck cell compartment of non-affected gastric mucosa (400x magnification).

Figure 3 Greatest increase in PCNA positive cells (brown colored cells) observed in gland compartment of gastric mucosa after PPI therapy (400x magnification).

Figure 4 Positive EGFR immunoreactivity (brown color) in parietal cells and mucus neck cells of fundic glands (200x magnification).

Figure 5 EGFR immunostaining (A) and immunoreactivity (B) after PPI therapy (200×magnification).