Effects of augmentation of liver regeneration recombinant plasmid on rat hepatic fibrosis

Figure 1 Histologic section of experimental groups (HE´200). A: Normal rat liver tissue, hepatic cords were well arranged; the structure of hepatic lobule was intact. B: Model rat liver tissue, collagen deposition extending from central veins, fibrotic septa and even pseudolobuli formation. C: ALR₁ group rat liver tissue, apparent amelioration of hepatocyte degeneration. D: ALR₂ group rat liver tissue, marked reduction in collagen deposition with no obvious pseudolobuli formation.

Figure 2 Immunohistochemistry section of TIMP-1 expressed (×200). A: Model rat liver tissue, positive staining was seen at interstitial cells, inflammatory cells, impaired hepatocytes as well as normal hepatocytes. B: ALR₁ group rat liver tissue, staining of TIMP-1 was decreased. C: ALR₂ group rat liver tissue, staining of TIMP-1 was markedly decreased.