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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2025; 31(33): 108653
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.108653
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.108653
Exosomes derived from human umbilical cord mesenchymal stem cells attenuate hepatic ischaemia-reperfusion injury via the let-7i-5p/Faslg axis
Yao Gao, Cong-Wen Bian, Rui Yu, Jia-Jiao Luo, Yin-Ming Xiang, Yun-Xin Yang, Han-Fei Huang, Zhong Zeng, The Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Min He, Department of Hepatic, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510440, Guangdong Province, China
Co-corresponding authors: Han-Fei Huang and Zhong Zeng.
Author contributions: Gao Y, Huang HF, Zeng Z, He M, and Bian CW contributed to project design; Gao Y, He M, Bian CW, Yu R, Luo JJ, Xiang YM, and Yang YX contributed to the experimental execution; Gao Y was responsible for data analysis and drafting of the initial manuscript; Yu R, Luo JJ, Xiang YM, and Yang YX contributed to the and data organization; Huang HF and Zeng Z contributed to the provided experimental guidance and research resources, participated in revision and proofreading, and made equal contributions as co-corresponding authors; and all authors reviewed and approved the final manuscript.
Supported by Natural Science Foundation Project of Yunnan Province, No. 202302AA310025 and No. 202449CE340016; and Health Research Project of Yunnan Province, No. 300068.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Kunming Medical University, No. KMMU20241598.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All data generated during this study are available from the corresponding authors upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Han-Fei Huang, Professor, The Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming 650032, Yunnan Province, China. huanghanfei@kmmu.edu.cn
Received: April 27, 2025
Revised: July 5, 2025
Accepted: August 5, 2025
Published online: September 7, 2025
Processing time: 128 Days and 0.1 Hours
Revised: July 5, 2025
Accepted: August 5, 2025
Published online: September 7, 2025
Processing time: 128 Days and 0.1 Hours
Core Tip
Core Tip: Human umbilical cord mesenchymal stem cell-derived exosomes mitigate hepatic ischaemia-reperfusion injury by targeting damaged hepatocytes via very late activation antigen-4/vascular cell adhesion molecule-1 and lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interactions. Their membrane proteins crucially mediate this specific protection, suppressing both the extrinsic and intrinsic apoptotic pathways. Central to this mechanism is the let-7i-5p/factor-related apoptosis ligand signaling axis.