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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2025; 31(30): 109585
Published online Aug 14, 2025. doi: 10.3748/wjg.v31.i30.109585
Published online Aug 14, 2025. doi: 10.3748/wjg.v31.i30.109585
Factors influencing diagnostic delays in celiac disease
Ting Li, Yan Feng, Man Wang, Feng Gao, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Ting Li, Yan Feng, Man Wang, Feng Gao, Xinjiang Clinical Research Center for Digestive Diseases, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Chun Wang, Department of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China
Co-first authors: Ting Li and Yan Feng.
Author contributions: Li T and Feng Y designed the research study and wrote the manuscript; Wang M and Feng Y performed the data acquisition and preliminary analysis; Li T and Wang C conducted in-depth data interpretation and result visualization; Gao F revised the manuscript critically and supervised the entire project, Feng Y provided financial support; Li T and Feng Y contributed equally to this study as co-first authors; all authors have read and approved the final manuscript.
Supported by Natural Science Foundation of the Xinjiang Autonomous Region, No. 2023D01C76; and Central Government Guide Local Science and Technology Development Special Fund Project, No. ZYYD2024JD1.
Institutional review board statement: This study was approved by the People's Hospital of Xinjiang Uygur Autonomous Region Review Board.
Informed consent statement: All participants signed a free and informed consent statement.
Conflict-of-interest statement: The authors did not provide a conflict of interest statement.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Gao, PhD, Chief Physician, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. xjgf0991@163.com
Received: May 16, 2025
Revised: June 8, 2025
Accepted: July 2, 2025
Published online: August 14, 2025
Processing time: 84 Days and 1.4 Hours
Revised: June 8, 2025
Accepted: July 2, 2025
Published online: August 14, 2025
Processing time: 84 Days and 1.4 Hours
Core Tip
Core Tip: This study presents the largest single-center cohort of Chinese celiac disease (CeD) patients (Marsh ≥ II histopathology) leveraging Xinjiang’s regional referral advantage. Among 166 CeD patients, 42.2% experienced diagnostic delay (> 2 years). Blood urea nitrogen (BUN) was identified as an independent risk factor (OR = 1.29), with risk significantly increasing at ≥ 4.3 mmol/L. Subgroup analyses showed stronger associations of BUN with diagnostic delay in females, patients with non-classical CeD phenotypes, Kazak individuals, and other subgroups. These findings highlight BUN as a novel predictor and provide evidence to prioritize high-risk subgroups for timely screening.