Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2025; 31(24): 108234
Published online Jun 28, 2025. doi: 10.3748/wjg.v31.i24.108234
Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats
Sarah Schulze, Sahar Keshvari, Gregory C Miller, Kim R Bridle, David A Hume, Katharine M Irvine
Sarah Schulze, Sahar Keshvari, David A Hume, Katharine M Irvine, Translational Research Institute, Mater Research Institute-The University of Queensland, Brisbane 4102, Queensland, Australia
Gregory C Miller, Envoi Pathology, Envoi Pathology, Brisbane 4000, Queensland, Australia
Kim R Bridle, Gallipoli Medical Research Institute, The University of Queensland, Greenslopes Private Hospital, Brisbane 4120, Queensland, Australia
Author contributions: Schulze S and Irvine KM were responsible for conceptualization; Schulze S, Keshvari S, Miller GC, Bridle KR, and Irvine KM were responsible for methodology, data collection and analysis; Schulze S and Irvine KM were responsible for draft manuscript; all authors were responsible for manuscript editing and review.
Supported by the German Research Foundation (Deutsche Forschungsgemeinschaft); and the Australian National Health and Medical Research Council and the Mater Foundation.
Institutional review board statement: The study was reviewed and approved by the University of Queensland Institutional Review Board (Approval No. IBC/1397/MRI/TRI/2022).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Queensland (Approval No. 2021_AE000958).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Katharine M Irvine, PhD, Associate Professor, Translational Research Institute, Mater Research Institute-University of Queensland, 37 Kent Street, Woolloongabba, Brisbane 4102, Queensland, Australia. katharine.irvine@uq.edu.au
Received: April 9, 2025
Revised: May 4, 2025
Accepted: June 4, 2025
Published online: June 28, 2025
Processing time: 79 Days and 1.1 Hours
Core Tip

Core Tip: During liver surgery, temporary interruption of blood flow followed by reperfusion can lead to tissue damage and inflammation. Macrophages and recruited monocytes can contribute to tissue damage and inflammation, but they are also necessary for injury resolution and prevention of post-operative infections. We show that perisurgical administration of the macrophage growth factor colony stimulating factor 1 promotes the accumulation of CD163+ pro-regenerative macrophages, reduces ischemia reperfusion-induced necrosis, and promotes liver growth in rats.