Redefining the treatment paradigm for esophageal gastrointestinal stromal tumors: The emerging role of endoscopic resection

doi:10.3748/wjg.v31.i24.106440

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Jun 28, 2025 (publication date) through Jun 26, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Jun 28, 2025; 31(24): 106440
Published online Jun 28, 2025. doi: 10.3748/wjg.v31.i24.106440

Redefining the treatment paradigm for esophageal gastrointestinal stromal tumors: The emerging role of endoscopic resection

Konstantin Semash, Timur Dzhanbekov

Konstantin Semash, Timur Dzhanbekov, Department of Mini-Invasive Surgery, National Children's Medical Center, Tashkent 100171, Uzbekistan

Co-first authors: Konstantin Semash and Timur Dzhanbekov.

Author contributions: Semash K and Dzhanbekov T jointly conceived the topic, performed the literature review, structured and drafted the manuscript, prepared the figures and table, and approved the final version of the article.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Konstantin Semash, MD, PhD, Department of Mini-Invasive Surgery, National Children's Medical Center, Parkent Street 294, Tashkent 100171, Uzbekistan. doctorsemash@gmail.com

Received: February 26, 2025
Revised: April 12, 2025
Accepted: June 5, 2025
Published online: June 28, 2025
Processing time: 120 Days and 11.3 Hours

Core Tip

Core Tip: Endoscopic resection (ER) is emerging as a minimally invasive alternative to traditional surgery for esophageal gastrointestinal stromal tumors (GISTs), particularly for tumors ≤ 4 cm with low mitotic activity. The study by Xu et al provides compelling evidence supporting ER’s high en bloc resection rate and favorable long-term outcomes. However, critical questions remain regarding patient selection criteria, the oncologic safety of R1 resections, and the role of adjuvant therapy. Further prospective studies are needed to define ER’s place in the treatment algorithm and optimize management strategies for esophageal GISTs.