Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2025; 31(19): 106814
Published online May 21, 2025. doi: 10.3748/wjg.v31.i19.106814
Current status of endoscopic resection for small rectal neuroendocrine tumors
Jian-Ning Liu, Hui Chen, Nian Fang
Jian-Ning Liu, Nian Fang, Department of Gastroenterology, The Third Affiliated Hospital, Jiangxi Medical College, School of Queen Mary, Nanchang University, Nanchang 330009, Jiangxi Province, China
Hui Chen, Endoscopic Center, Xijing Hospital of Digestive Diseases, Air Force Medical University (Fourth Military Medical University), Xi’an 710032, Shaanxi Province, China
Nian Fang, Department of Gastroenterology, The First Hospital of Nanchang, Nanchang 330009, Jiangxi Province, China
Co-corresponding authors: Hui Chen and Nian Fang.
Author contributions: Liu JN conceptualized the study, conducted the literature review and drafted the manuscript, created the artwork; Chen H and Fang N both supervised and made critical revisions, and all authors have read and approved the final manuscript. Chen H and Fang N equally contributed to the current manuscript as co-corresponding authors by providing instructive guidance and critical revisions.
Supported by Nanchang High-Level Scientific and Technological Innovation Talents ‘Double Hundred Plan’ Project, China, No. 2022-312.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nian Fang, PhD, Professor, Department of Gastroenterology, The Third Affiliated Hospital, Jiangxi Medical College, School of Queen Mary, Nanchang University, No. 128 Xiangshan North Road, Nanchang 330009, Jiangxi Province, China. nianfang_ncu@163.com
Received: March 9, 2025
Revised: March 21, 2025
Accepted: April 27, 2025
Published online: May 21, 2025
Processing time: 74 Days and 18.3 Hours
Core Tip

Core Tip: The initial evaluation of small rectal neuroendocrine tumors should thoroughly assess endoscopic features, including size, location, surface pit pattern and atypical changes. Imaging modalities should be used to rule out possible lymph node involvement and distant metastasis. Cold biopsy or polypectomy should be avoided, and modified endoscopic mucosal resection with submucosal stretching should be chosen as a priority. For small incompletely resected tumors without other risk factors, salvage resection can be carefully considered. Long-term follow-up is necessary if patients decline additional treatment. For patients with complete resection and risk factors, extended follow-up should be considered.