Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2025; 31(18): 105530
Published online May 14, 2025. doi: 10.3748/wjg.v31.i18.105530
Laparoscopic associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastases: A single-center experience
Zhe-Yu Zheng, Lei Zhang, Wen-Li Li, Shu-Yi Dong, Jing-Lin Song, Da-Wei Zhang, Xiao-Ming Huang, Wei-Dong Pan
Zhe-Yu Zheng, Lei Zhang, Shu-Yi Dong, Jing-Lin Song, Da-Wei Zhang, Xiao-Ming Huang, Wei-Dong Pan, Department of Pancreatic Hepatobiliary Surgery, Department of General Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China
Zhe-Yu Zheng, Lei Zhang, Wen-Li Li, Shu-Yi Dong, Jing-Lin Song, Da-Wei Zhang, Xiao-Ming Huang, Wei-Dong Pan, Biomedical Innovation Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China
Wen-Li Li, Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China
Co-corresponding authors: Xiao-Ming Huang and Wei-Dong Pan.
Author contributions: Zheng ZY, Zhang L, Li WL, Dong SY, and Song JL contributed to acquisition of data, analysis and interpretation of data, drafting of the manuscript, and statistical analysis; Zhang DW, Huang XM, and Pan WD contributed to study concept and design, obtained funding and material support, study supervision and critical revision of the manuscript for important intellectual content; and all authors of this research have approved the final version of the article. Zhang DW, Huang XM, and Pan WD contributed equally to this work, Huang XM and Pan WD as the co-corresponding authors of this manuscript.
Supported by Natural Science Foundation of Guangdong Province of China, No. 2024A1515012862.
Institutional review board statement: Data collection for this study was approved by the Ethics Committee of the Sixth Affiliated Hospital of Sun Yat-sen University (Approval No. 2022ZSLYEC-130).
Informed consent statement: Informed consent was obtained from all participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets analyzed during the current study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Dong Pan, MD, Chief Physician, Professor, Department of Pancreatic Hepatobiliary Surgery, Department of General Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 26 Erheng Road, Tianhe District, Guangzhou 510655, Guangdong Province, China. panwd@mail.sysu.edu.cn
Received: January 27, 2025
Revised: February 27, 2025
Accepted: April 24, 2025
Published online: May 14, 2025
Processing time: 107 Days and 7.6 Hours
Core Tip

Core Tip: This study evaluates the feasibility and safety of full laparoscopic associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in colorectal liver metastases. Among 15 patients, the procedure achieved a 100% radical resection rate with significant future liver remnant hypertrophy (47% median increase). Complication rates were low, particularly in stage 1, with no mortality reported. Laparoscopic modifications minimized invasiveness and enhanced surgical outcomes. Post-ALPPS liver regeneration was substantial, demonstrating the potential for repeat interventions. These findings support full laparoscopic ALPPS as a promising strategy for advanced colorectal liver metastases, addressing the limitations of traditional hypertrophy techniques like portal venous embolization or portal venous ligation.