Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2024; 30(5): 429-439
Published online Feb 7, 2024. doi: 10.3748/wjg.v30.i5.429
Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives
Ya-Wei Bi, Long-Song Li, Nan Ru, Bo Zhang, Xiao Lei
Ya-Wei Bi, Long-Song Li, Nan Ru, Bo Zhang, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Xiao Lei, Department of Radiation Oncology, Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: Ya-Wei Bi and Long-Song Li.
Author contributions: Bi YW, Li LS, and Ru N retrieved concerned literatures and made the manuscript; Bi YW and Zhang B designed the figures; Lei X participated in the revision of manuscript; and all authors read and approved the final manuscript.
Supported by Youth Independent Innovation Science Fund Project from Chinese PLA General Hospital, No. 22QNFC075.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiao Lei, PhD, Chief Physician, Doctor, Department of Radiation Oncology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
Received: September 26, 2023
Peer-review started: September 26, 2023
First decision: December 7, 2023
Revised: December 17, 2023
Accepted: January 12, 2024
Article in press: January 12, 2024
Published online: February 7, 2024
Core Tip

Core Tip: Nicotinamide adenine dinucleotide phosphate hydrogen oxides (NOX) plays a significant role in the development of pancreatitis and pancreatic cancer (PC) by contributing to pancreatic fibrosis and inflammation. It achieves this by generating reactive oxygen species, which damage acinar cells, activate pancreatic stellate cells, and induce macrophage polarization. Moreover, NOX promotes PC progression by interfering with abnormal cell apoptosis, initiating the epithelial to mesenchymal transition processes, and leading to cell genomic instability. A thorough understanding of NOX’s involvement in pancreatic diseases is crucial for comprehending the underlying mechanisms of pancreatitis and PC. This review provides a summary of NOX’s potential roles and mechanisms in pancreatic disorders, emphasizing areas that require further investigation.