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World J Gastroenterol. Sep 28, 2023; 29(36): 5211-5225
Published online Sep 28, 2023. doi: 10.3748/wjg.v29.i36.5211
Integration and implementation of precision medicine in the multifaceted inflammatory bowel disease
Gowthami Sai Kogilathota Jagirdhar, Jose Andres Perez, Andrea Belen Perez, Salim Surani
Gowthami Sai Kogilathota Jagirdhar, Department of Medicine, Saint Francis Health Science Center, Newark, NJ 07107, United States
Jose Andres Perez, Department of Medicine, Saint Francis Health Systems, Tulsa, OK 74133, United States
Andrea Belen Perez, Department of Research, Columbia University, New York, NY 10027, United States
Salim Surani, Department of Medicine and Pharmacology, Texas A&M University, College Station, TX 77413, United States
Author contributions: Jagirdhar GSK, Perez JA, and Perez AB performed the literature review, wrote the original manuscript; Surani S wrote the original manuscript, revised the paper, and approved the final version.
Conflict-of-interest statement: None of the co-authors declared any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Salim Surani, FCCP, MD, MHSc, Academic Editor, Professor, Department of Medicine and Pharmacology, Texas A&M University, 400 Bizzell Street, College Station, TX 77413, United States. srsurani@hotmail.com
Received: July 1, 2023
Peer-review started: July 1, 2023
First decision: July 10, 2023
Revised: July 31, 2023
Accepted: September 6, 2023
Article in press: September 6, 2023
Published online: September 28, 2023
Core Tip

Core Tip: Precision medicine holds significant promise in managing inflammatory bowel disease (IBD) by aiming to customize treatments based on the unique biological characteristics of patients. Despite advancements in biological and small-molecule therapies offering new therapeutic options for IBD; however, the is a large gap in understanding the clinical course of IBD, the durability of treatment response, and enhancing available and new therapeutic options. Integrating multiomics into patient care can help in early diagnosis, predict disease course, deliver targeted treatments based on unique patient profiles, and evaluate prognosis.