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World J Gastroenterol. Jan 21, 2023; 29(3): 425-449
Published online Jan 21, 2023. doi: 10.3748/wjg.v29.i3.425
COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells
Fares E M Ali, Mostafa K Abd El-Aziz, Mahmoud M Ali, Osama M Ghogar, Adel G Bakr
Fares E M Ali, Adel G Bakr, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt
Mostafa K Abd El-Aziz, Mahmoud M Ali, Department of Pharmacology, Al-Azhar University, Assiut 71524, Egypt
Osama M Ghogar, Department of Biochemistry Faculty of Pharmacy, Badr University in Assiut, Egypt
Author contributions: Ali FEM designed and critically wrote the manuscript; Abd El-Aziz MK, Ali MM, Ghogar OM collected the data and drafted the manuscript, Bakr AG contributed to manuscript revision and proof editing.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Fares E M Ali, MSc, PhD, Lecturer, Research Scientist, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Al-Azhar Street, Assiut 71524, Egypt.
Received: September 13, 2022
Peer-review started: September 13, 2022
First decision: October 30, 2022
Revised: November 15, 2022
Accepted: December 23, 2022
Article in press: December 23, 2022
Published online: January 21, 2023
Core Tip

Core Tip: The association between coronavirus disease-19 and hepatic injury is demonstrated by determining the viral tropism and its different pathological implications. A better understanding of the diversity and risk factors of severe acute respiratory syndrome coronavirus-2-induced hepatic injury provides a fundamental approach to overcoming adverse effects. Moreover, vaccination can influence assessment and evaluation.