Minireviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2023; 29(2): 357-366
Published online Jan 14, 2023. doi: 10.3748/wjg.v29.i2.357
Secondary bile acids and the biliary epithelia: The good and the bad
Ilaria Lenci, Martina Milana, Alessandro Signorello, Giuseppe Grassi, Leonardo Baiocchi
Ilaria Lenci, Martina Milana, Alessandro Signorello, Giuseppe Grassi, Leonardo Baiocchi, Hepatology Unit, Policlinico Tor Vergata, Rome 00133, Italy
Author contributions: Lenci I contributed to the acquisition of data, analysis and interpretation, drafting of manuscript and critical revision; Milana M, Signorello A and Grassi G contributed to the acquisition of data and critical revision; Baiocchi L contributed to the proposal of study, study conception, correction of manuscript and critical revision.
Conflict-of-interest statement: The authors declare no conflict-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Leonardo Baiocchi, MD, PhD, Associate Professor, Hepatology Unit, Policlinico Tor Vergata, Via Montpellier 1, Rome 00133, Italy. baiocchi@uniroma2.it
Received: September 23, 2022
Peer-review started: September 23, 2022
First decision: October 30, 2022
Revised: November 12, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 14, 2023
Core Tip

Core Tip: The biliary epithelia present important physiologic activities that are of interest with regard to chronic cholestatic liver diseases. Secondary bile acids (BAs) are derived by bacterial manipulation of the primary BAs produced by the liver. This review summarizes the most important recent findings with regard to secondary BAs interaction with biliary epithelia.