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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2022; 28(44): 6258-6270
Published online Nov 28, 2022. doi: 10.3748/wjg.v28.i44.6258
Published online Nov 28, 2022. doi: 10.3748/wjg.v28.i44.6258
Glucagon-like peptide-2 analogues for Crohn’s disease patients with short bowel syndrome and intestinal failure
Marco Pizzoferrato, Pierluigi Puca, Sara Ennas, Giovanni Cammarota, Luisa Guidi, UOC Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome 00168, Italy
Pierluigi Puca, Giovanni Cammarota, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome 00168, Italy
Author contributions: All authors contributed to the conception and design of the study, drafting the article or making critical revisions related to important intellectual content of the manuscript; Pizzoferrato M, Cammarota G and Guidi L involved in the final approval of the version of the article to be published.
Conflict-of-interest statement: Guidi L consulted and/or lecture fees: AbbVie, Janssen, Pfizer, Shire, Takeda. All the other authors declare that they have no affiliations with or involvement in any organization or entity with any financial interest in the subject matter or materials discussed in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Luisa Guidi, MD, PhD, Professor, UOC Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli, 8, Rome 00168, Italy. luisa.guidi@policlinicogemelli.it
Received: September 10, 2022
Peer-review started: September 10, 2022
First decision: October 19, 2022
Revised: November 1, 2022
Accepted: November 17, 2022
Article in press: November 17, 2022
Published online: November 28, 2022
Peer-review started: September 10, 2022
First decision: October 19, 2022
Revised: November 1, 2022
Accepted: November 17, 2022
Article in press: November 17, 2022
Published online: November 28, 2022
Core Tip
Core Tip: Short bowel syndrome with intestinal failure and chronic dependency on parenteral support are rare but severe complications of Crohn’s disease (CD) after repeated intestinal resections. New therapeutic options are available, including glucagon-like peptide-2 analogues. Their use in CD appears safe and efficacious, but more data from specifically designed studies are needed.