Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2022; 28(31): 4263-4298
Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4263
Evidence-based pathogenesis and treatment of ulcerative colitis: A causal role for colonic epithelial hydrogen peroxide
Jay Pravda
Jay Pravda, Disease Pathogenesis, Inflammatory Disease Research Centre, Palm Beach Gardens, FL 33410, United States
Author contributions: Pravda J is the sole author of this manuscript and solely responsible for its content; Pravda J performed all the research, collected, analyzed, and interpreted all the data; Pravda J conceived of and developed the hydrogen peroxide-based pathogenesis of ulcerative colitis; Pravda J prepared and wrote the manuscript and performed all critical revisions; Pravda J certifies that this manuscript is the product of his original research; and Pravda J has overall responsibility for this manuscript.
Conflict-of-interest statement: The author reported no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jay Pravda, MD, Research Scientist, Senior Researcher, Disease Pathogenesis, Inflammatory Disease Research Centre, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States.
Received: January 25, 2022
Peer-review started: January 25, 2022
First decision: April 10, 2022
Revised: April 19, 2022
Accepted: July 20, 2022
Article in press: July 20, 2022
Published online: August 21, 2022
Core Tip

Core Tip: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that has resisted all efforts to uncover its cause and cure. However, an evidence-based systems medicine approach has provided compelling evidence that the secretion of hydrogen peroxide (H2O2) from colonic epithelial cells is the etiological agent responsible for this debilitating illness. H2O2 is a highly potent chemotactic agent that can attract neutrophils into the colonic epithelium, and significantly elevated production of H2O2 has been documented in the non-inflamed colonic epithelium of individuals with UC. Treatment to normalize colonic H2O2 leads to long-lasting histologic remission.