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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2022; 28(29): 3971-3980
Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3971
Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3971
Effects of microwave ablation on serum Golgi protein 73 in patients with primary liver cancer
Zheng-Ju Xu, Hui-Guo Liu, Jin-Piao Wu, Jin-Fa Huang, Yong-Fei Li, Zhi-Jie Huang, Yan-Yan Yan, The Liver Disease Center, The 910th Hospital of the PLA Joint Logistics Support Force, Quanzhou 362000, Fujian Province, China
Mei-Juan Wei, Central Laboratory, Decheng Hospital, Quanzhou 362104, Fujian Province, China
Xiao-Man Zhang, Central Laboratory of Clinical Hepatology, The 910th Hospital of the PLA Joint Logistics Support Force, Quanzhou 362000, Fujian Province, China
Author contributions: Xu ZJ carried out the design, coordination of experimental work, manuscript writing, and also performed the microwave ablation procedure; Wei MJ and Zhang XM participated in the study design and data analysis; Liu HG, Wu JP, Huang JF, Li YF, Huang ZJ, and Yan YY participated in data collection and analysis; all authors read and approved the final manuscript.
Supported by the Military Medical Science and Technology Committee of China , No. 14MS095 ; and the Quanzhou Science and Technology Planning Project , No. 2017Z018 .
Institutional review board statement: The study was reviewed and approved by the 910th Hospital of the PLA Joint Logistics Support Force Institutional Review Board.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: Xu ZJ has received research funding from the Military Medical Science and Technology Committee of China, No. 14MS095, and grants from the Quanzhou Science and Technology Planning Project, No. 2017Z018, during the conduct of the study.
Data sharing statement: Technical appendix and dataset available from the corresponding author at " h180@163.com ". Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng-Ju Xu, MD, Chief Doctor, The Liver Disease Center, The 910th Hospital of the PLA Joint Logistics Support Force, No. 180 Huayuan Road, Fengze District, Quanzhou 362000, Fujian Province, China. h180@163.com
Received: February 21, 2022
Peer-review started: February 21, 2022
First decision: April 16, 2022
Revised: April 30, 2022
Accepted: July 5, 2022
Article in press: July 5, 2022
Published online: August 7, 2022
Peer-review started: February 21, 2022
First decision: April 16, 2022
Revised: April 30, 2022
Accepted: July 5, 2022
Article in press: July 5, 2022
Published online: August 7, 2022
Core Tip
Core Tip: Microwave ablation (MWA) has become an effective modality of cancer treatment, including primary liver cancer. However, the MWA procedure induces a hepatic inflammatory response and injury, which may diminish the efficacy of MWA. Therefore, the discovery of reliable markers to monitor the response to MWA is still needed. In this study, we examined the effects of MWA on the serum levels of Golgi protein 73 (GP73). The resulting data suggest that serum GP73 is markedly elevated in response to the MWA procedure. Importantly, our novel findings may have the clinical implication that serum GP73 could be a potential marker to monitor MWA-induced inflammatory liver injury.