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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2022; 28(29): 3838-3853
Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3838
Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3838
High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1
Dong Chen, Jin-Hai Wang, Sai-Sai Wang, Xiao-Fei Cheng, Department of Colorectal Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Miao-Miao Lu, Yue Ren, Ling-Ling Xu, Wei-Xin Cheng, Farhin Shaheed Kalyani, Department of Medicine, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Xiao-Lin Li, Department of Emergency, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Jian-Guo Gao, Xi Jin, Department of Gastroenterology, The First affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Jin X designed the report; Chen D performed experiments and statistical analysis; Lu MM wrote the paper and assisted to design the report; Wang JH, Ren Y, Wang SS, Xu LL, Cheng XF, Cheng WX, Gao JG, and Li XL assisted to perform experiments and analyzed data; Kalyani FS assisted with paper writing; all authors had access to the study data and reviewed and approved the final manuscript.
Supported by the National Natural Science Foundation of China , No. 81770574 ; and the Natural Science Foundation of Zhejiang Province , No. LZ21H030002 and No. LY21H030005 .
Institutional animal care and use committee statement: The study was reviewed and approved by the institutional review board of the Tab of Animal Experimental Ethical Inspection of the First Affiliated Hospital of Zhejiang University, NO. 2020-1101.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: All the data included in this study are available upon request by contact with the corresponding author.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xi Jin, MD, PhD, Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. jxfl007@zju.edu.cn
Received: December 4, 2021
Peer-review started: December 4, 2021
First decision: April 16, 2022
Revised: April 28, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 7, 2022
Peer-review started: December 4, 2021
First decision: April 16, 2022
Revised: April 28, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 7, 2022
Core Tip
Core Tip: A higher visceral adipose tissue ratio has been associated with increased disease activity in patients with Crohn’s disease. However, the mechanisms underlying this effect remain unclear. Our study indicates that a high-fat diet increases the mesenteric adipose tissue content and aggravates colitis in mice. Mesenteric adipose tissue-derived exosome long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 can be absorbed by the colon, leading to the activation of the endoplasmic reticulum stress pathway by targeting the miR-15a-5p/activating transcription factor 6 axis to aggravate colitis.