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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2021; 27(6): 513-522
Published online Feb 14, 2021. doi: 10.3748/wjg.v27.i6.513
Published online Feb 14, 2021. doi: 10.3748/wjg.v27.i6.513
Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease
Ya-Mei Zheng, Xian-Yun Chen, Jie-Yi Cai, Yu Yuan, Wen-Rui Xie, Jia-Ting Xu, Xing-Xiang He, Li-Hao Wu, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, Guangzhou 510030, Guangdong Province, China
Harry Hua-Xiang Xia, Department of Science and Education, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China
Min Zhang, Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou 510220, Guangdong Province, China
Author contributions: Zheng YM contributed to the study design, performed the experiments, and wrote the paper; Wu LH contributed to the study design, provided critical revision of the article for important intellectual content, and made final approval of the article; Chen XY, Cai JY, Zhang M, and Xia HHX designed the study and contributed to the analysis and interpretation of the data; Yuan Y, Xie WR, He XX, and Xu JT provided clinical advice and supervised the report.
Institutional review board statement: This retrospective study was approved by the Ethics Committee of Guangdong Pharmaceutical University (Approval No. Yilun Shen[2019] No. 93 01).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Hao Wu, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510030, Guangdong Province, China. wulihao888@126.com
Received: November 29, 2020
Peer-review started: November 29, 2020
First decision: December 8, 2020
Revised: December 20, 2020
Accepted: January 12, 2021
Article in press: January 12, 2021
Published online: February 14, 2021
Processing time: 67 Days and 23.6 Hours
Peer-review started: November 29, 2020
First decision: December 8, 2020
Revised: December 20, 2020
Accepted: January 12, 2021
Article in press: January 12, 2021
Published online: February 14, 2021
Processing time: 67 Days and 23.6 Hours
Core Tip
Core Tip: In this study, we demonstrated for the first time that washed microbiota transplantation (WMT) is safe and effective for treating patients with nonerosive reflux disease (NERD) and proton pump inhibitor (PPI) dependency compared with PPI treatment. WMT significantly relieved the symptoms of NERD in patients, reduced PPI dependency, prolonged the duration of symptom remission, and reduced symptom recurrence.