Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2021; 27(5): 377-390
Published online Feb 7, 2021. doi: 10.3748/wjg.v27.i5.377
Liver injury in the era of COVID-19
Halina Cichoż-Lach, Agata Michalak
Halina Cichoż-Lach, Agata Michalak, Department of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Jaczewskiego 8, Lublin 20-954, Poland
Author contributions: Cichoż-Lach H designed and coordinated the study; Michalak A acquired and analyzed the data; Cichoż-Lach H and Michalak A wrote the manuscript; all authors approved the final version of the article.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Halina Cichoż-Lach, PhD, Full Professor, Department of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Jaczewskiego 8, Lublin 20-954, Poland.
Received: October 20, 2020
Peer-review started: October 20, 2020
First decision: December 18, 2020
Revised: December 25, 2020
Accepted: January 8, 2021
Article in press: January 8, 2021
Published online: February 7, 2021
Core Tip

Core Tip: The coronavirus disease 2019 (COVID-19) pandemic has revolutionized the priorities of the medical society worldwide. In the natural history of severe acute respiratory syndrome coronavirus-2 infection, liver injury is relatively frequent but quite mild and it is described as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver disorders. Direct viral cytopathic injury, secondary liver impairment due to systemic inflammatory response or hypoxia, drug-induced liver failure and finally the exacerbation of chronic liver diseases are enumerated as potential etiologic factors for liver injury in COVID-19.