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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2021; 27(41): 7065-7079
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7065
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7065
Gut microbiota in a population highly affected by obesity and type 2 diabetes and susceptibility to COVID-19
Jaime García-Mena, Karina Corona-Cervantes, Tizziani Benitez-Guerrero, Juan Manuel Vélez-Ixta, Norma Gabriela Zavala-Torres, Loan Edel Villalobos-Flores, Fernando Hernández-Quiroz, Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, CDMX, Mexico
Daniel Cuervo-Zanatta, Departamento de Genética y Biología Molecular and Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, CDMX, Mexico
Claudia Perez-Cruz, Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, CDMX, Mexico
Selvasankar Murugesan, Department of Mother and Child Health, SIDRA Medicine, Doha 26999, Qatar
Fernando Guadalupe Bastida-González, Laboratorio Estatal de Salud Pública del Estado de México, ISEM, Toluca de Lerdo 50180, Estado de México, Mexico
Paola Berenice Zárate-Segura, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, CDMX, Mexico
Author contributions: García-Mena J, Corona-Cervantes K, Cuervo-Zanatta D, Benitez-Guerrero T, Vélez-Ixta JM, Zavala-Torres NG, Villalobos-Flores LE, Hernández-Quiroz F, Pérez-Cruz C, Murugesan S, Bastida-González FG, Zárate-Segura PB, contributed equally to conceptualization and design, paper writing, critical review, and approved the final version of the paper.
Supported by Secretaría de Relaciones Exteriores México (SRE) , No. SRE/027/2021 ; Agencia Mexicana de Cooperación Internacional para el Desarrollo (AMEXCID) , No. AMEXCID 2020-5 ; CONACyT for Doctoral Fellowships , No. 777953 (KC-C), No. 635676 (TB-G), No. 291236 (FH-Q), and No. 336296 (LEV-F); CONACyT for Master Fellowships , No. 997494 (NGZ-T), and No. 997152 (JMV-I); Fellows from the Sistema Nacional de Investigadores , Mexico, No. 43142 (PZ-S), No. 225525 (FB-G), No. 47399 (CP-C), and No. 19815 (JG-M).
Conflict-of-interest statement: The authors report no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jaime García-Mena, PhD, Professor, Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Col Zacatenco, Mexico City 07360, CDMX, Mexico. jgmena@cinvestav.mx
Received: May 1, 2021
Peer-review started: May 1, 2021
First decision: June 12, 2021
Revised: June 25, 2021
Accepted: September 30, 2021
Article in press: September 30, 2021
Published online: November 7, 2021
Peer-review started: May 1, 2021
First decision: June 12, 2021
Revised: June 25, 2021
Accepted: September 30, 2021
Article in press: September 30, 2021
Published online: November 7, 2021
Core Tip
Core Tip: This work reviews recent data about gut microbiota (GM) diversity in Mexico, a country in which more than 18.4% of adults present high blood pressure, 39.1% are overweight, 36.1% are obese, and more than 10.3% suffer from type 2 diabetes. This review highlights the link between GM dysbiosis and severe acute respiratory syndrome coronavirus 2 prevalence, which ranks Mexico third in cumu