Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

doi:10.3748/wjg.v27.i41.7025

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Nov 7, 2021 (publication date) through May 9, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 7, 2021; 27(41): 7025-7040
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7025

Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

María Belén Novoa Díaz, Pedro Matías Carriere, María Julia Martín, Natalia Calvo, Claudia Gentili

María Belén Novoa Díaz, Pedro Matías Carriere, María Julia Martín, Natalia Calvo, Claudia Gentili, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), Bahía Blanca 8000, Buenos Aires, Argentina

María Julia Martín, Departamento de Química, Universidad Nacional del Sur (UNS)- INQUISUR (CONICET-UNS), Bahía Blanca 8000, Buenos Aires, Argentina

Author contributions: Calvo N and Gentili C supervised this project; Gentili C was responsible for the project administration and funding acquisition and provided the resources; All authors were involved in conceptualization, methodology, investigation, formal analysis, visualization, writing original draft, writing-review and editing.

Supported by Agencia Nacional de Promoción Científica y Tecnológica, No. PICT-2013-1441; Consejo Nacional de Investigaciones Científicas y Técnicas, No. PIP11220150100350; Instituto Nacional del Cáncer, Asistencia financiera II, No. 12002-4395-14-1; Instituto Nacional del Cáncer, Asistencia Financiera III, No. RESOL-2016-1006-E-APN-MS; and Universidad Nacional del Sur, Argentina, No. PGI: 24/B230; PGI: 24/B303.

Conflict-of-interest statement: Authors declare no conflict of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Corresponding author: Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)- INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar

Received: April 27, 2021
Peer-review started: April 27, 2021
First decision: June 13, 2021
Revised: June 14, 2021
Accepted: August 23, 2021
Article in press: August 23, 2021
Published online: November 7, 2021

Core Tip

Core Tip: In colorectal cancer (CRC) cells, we found that parathyroid hormone-related peptide (PTHrP) promotes survival, cell cycle progression, proliferation, migration and chemoresistance and also modulates markers expression associated with invasion, angiogenesis, epithelial to mesenchymal transition and cancer stem cells features. In vivo tests indicate that PTHrP administration increases the expression of several markers related to tumorigenic events. Recently, we observed that PTHrP influences on tumor microenvironment cells, inducing events associated with the progression of CRC. Our project focuses in understanding the biology of CRC and the underlying mechanisms related to the aggressive behavior of CRC cells with the aim to identify new markers that improve the diagnosis, prognosis and therapy of CRC.