Published online Jul 28, 2021. doi: 10.3748/wjg.v27.i28.4555
Peer-review started: January 27, 2021
First decision: March 29, 2021
Revised: April 4, 2021
Accepted: July 9, 2021
Article in press: July 9, 2021
Published online: July 28, 2021
Core Tip: The hepatitis C virus (HCV) depends on its host cells to propagate successfully. Hundreds of cellular factors involved in the HCV life cycle have been identified. Some of these cellular factors are potential targets for anti-HCV therapies (e.g., scavenger receptor class B type 1, epidermal growth factor receptor, Niemann–Pick C1-like 1, microRNA-122, cyclophilin A). A successful vaccine for HCV is still a challenge in the near future. Investigating the cellular factors involved in viral entry should help vaccine development. HCV is also a unique model to study the interactions between viral infection and cellular lipid metabolisms.