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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2021; 27(27): 4453-4467
Published online Jul 21, 2021. doi: 10.3748/wjg.v27.i27.4453
Published online Jul 21, 2021. doi: 10.3748/wjg.v27.i27.4453
Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in hepatocellular carcinoma
Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, South Korea
Author contributions: Choi GH, and Jeong SH were responsible for the study concept and design, data acquisition, analysis, and interpretation, statistical analysis, and manuscript drafting; Jang ES and Kim JW assisted in data acquisition, analysis, and interpretation.
Supported by Seoul National University Bundang Hospital Research Fund , No. 02-2019-037 .
Institutional review board statement: This study approval by the Institutional Review Board (IRB) of the SNUBH, No. B-1201/143-002.
Informed consent statement: Written informed consent was obtained from each HCC patient after approval by the Institutional Review Board (IRB) of the SNUBH, No. B-1201/143-002.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: We regret, but we are not willing to share data.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sook-Hyang Jeong, PhD, Professor, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Seongnam 13620, South Korea. jsh@snubh.org
Received: February 21, 2021
Peer-review started: February 21, 2021
First decision: May 13, 2021
Revised: May 16, 2021
Accepted: July 7, 2021
Article in press: July 7, 2021
Published online: July 21, 2021
Peer-review started: February 21, 2021
First decision: May 13, 2021
Revised: May 16, 2021
Accepted: July 7, 2021
Article in press: July 7, 2021
Published online: July 21, 2021
Core Tip
Core Tip: Most hepatocellular carcinomas (HCCs) are hypervascular tumor, thus angiogenesis markers can be a potential biomarker. This study explored the potential of each plasma level of angiopoietin (Ang)-1, Ang-2, and vascular endothelial growth factor as a prognostic biomarker for very early to advanced stages of HCC via detailed analysis in comparison with alpha-fetoprotein. The plasma level of Ang-2 correlated with liver function, tumor stage, and tumor invasiveness. Multivariable and propensity score-matched analyses revealed Ang-2 levels with the highest predictive power for overall survival in patients with HCC.