Opinion Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2021; 27(26): 3971-3983
Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.3971
Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion
Yi-Wen Shi, Rui-Xu Yang, Jian-Gao Fan
Yi-Wen Shi, Rui-Xu Yang, Jian-Gao Fan, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China
Author contributions: Shi YW, Yang RX and Fan JG contributed to the study concept and design; Shi YW and Fan JG contributed to drafting the manuscript; Fan JG contributed to critical revision of the manuscript for important intellectual content; All authors confirmed critical revision of the manuscript for important intellectual content.
Supported by National Key Research and Development Program of China, No. 2017YFC0908903; and National Natural Science Foundation of China, No. 81873565 and No. 81900507.
Conflict-of-interest statement: The authors declare that theyhaveno competinginterests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Gao Fan, MD, PhD, Chief Physician, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, No. 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Received: February 6, 2021
Peer-review started: February 6, 2021
First decision: April 19, 2021
Revised: April 28, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: July 14, 2021
Core Tip

Core Tip: The pathophysiology of concomitant hepatitis B and hepatic steatosis remains unclear. This review comprehensively discusses the epidemiology, risk factors, long-term outcomes, histological assessment, potential mechanisms, and therapeutic options in this field. We believe further studies can clarify the interactions of hepatitis B virus and steatosis, and provide novel strategies for the management of hepatitis B patients with concomitant steatosis.