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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2021; 27(24): 3682-3692
Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3682
Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3682
Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and meta-analysis
Sushrut Trakroo, Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Nakul Bhardwaj, Rajat Garg, Department of Internal Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Jamak Modaresi Esfeh, Department of Gastroenterology and Transplant Hepatology, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Trakroo S designed the study, did the data acquisition, helped analyzed and interpreted data, drafted and made critical revisions to manuscript content and made final revisions before publication; Bhardwaj N helped analyze the data, drafted the manuscript, made critical revisions to the manuscript and helped make final revisions before publication; Garg R substantially contributed to data analysis and interpretation, made critical revisions to the manuscript and helped in the final approval of article before publication; Modaresi Esfeh J conceptualized the study, designed the study, helped with drafting of the article, made critical revisions to the content of manuscript, helped with data analysis and did the final approval of the version of the article before publication.
Conflict-of-interest statement: There are no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jamak Modaresi Esfeh, MD, Staff Physician, Department of Gastroenterology and Transplant Hepatology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States. modarej@ccf.org
Received: January 24, 2021
Peer-review started: January 24, 2021
First decision: February 23, 2021
Revised: March 8, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: June 28, 2021
Peer-review started: January 24, 2021
First decision: February 23, 2021
Revised: March 8, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: June 28, 2021
Core Tip
Core Tip: Living donor liver transplantation is an established modality in expanding the donor pool but is limited by donor safety concerns and recipient and graft outcomes due to high prevalence of hepatic steatosis in obese or overweight donors. Weight loss is known to improve or resolve steatosis and help convert marginal donors to low-risk donors in a small series of studies. Our meta-analysis demonstrates that short term weight loss intervention, is feasible and safe in significantly reducing hepatic steatosis in living liver donors undergoing donor evaluation and has the potential to safely expand the donor pool.