Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2270
Peer-review started: January 24, 2021
First decision: February 22, 2021
Revised: February 22, 2021
Accepted: April 13, 2021
Article in press: April 13, 2021
Published online: May 21, 2021
Core Tip: Data raised during the pandemic suggest that inflammatory bowel diseases do not have an increased risk of contracting severe acute respiratory syndrome coronavirus 2 infection or develop a more severe course of infection. These findings are in some way unexpected considering that inflammatory bowel disease is a chronic inflammatory state of the gastrointestinal tract. We herein discuss how the receptor for advanced glycation end-products axis activation as well as the cross-talk with the renin-angiotensin system are dampened by the high expression of soluble forms of both receptor for advanced glycation end-products and angiotensin-converting enzyme 2.