Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2021; 27(15): 1643-1654
Published online Apr 21, 2021. doi: 10.3748/wjg.v27.i15.1643
Intestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome
Xue-Ying Liang, Tian-Xu Jia, Mei Zhang
Xue-Ying Liang, Tian-Xu Jia, Mei Zhang, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Author contributions: Liang XY made substantial contributions to the conception and design of the study, acquisition, analysis, and interpretation of data, and drafting the article; Jia TX made substantial contributions to the acquisition and analysis of data; Zhang M made substantial contributions to the conception, design and guide of the study; all authors read and approved the final manuscript.
Supported by Beijing Municipal Education Commission Science and Technology Plan General Project, No. KM201310025015.
Institutional review board statement: The study was reviewed and approved by the Department of Gastroenterology of Xuanwu Hospital, Capital Medical University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare the absence of conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mei Zhang, PhD, Chief Physician, Doctor, Professor, Department of Gastroenterology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xuanwu District, Beijing 100053, China.
Received: December 22, 2020
Peer-review started: December 22, 2020
First decision: January 27, 2021
Revised: February 4, 2021
Accepted: March 10, 2021
Article in press: March 10, 2021
Published online: April 21, 2021
Core Tip

Core Tip: Our retrospective study included 149 patients with acute pancreatic disease. The changes in intestinal flora were detected by the hydrogen breath test. We found that the change in intestinal flora in patients with severe acute pancreatitis was related to acute respiratory distress syndrome, which can aggravate the disease. The results of the hydrogen breath test can be used as a warning signal for severe acute pancreatitis.