Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice
Chieko Tashita, Kentaro Nakamoto, Tatsuya Ando, Yasuko Yamamoto, Kuniaki Saito, Department of Disease Control and Prevention, Fujita Health University Graduate School of Health Sciences, Toyoake 470-1192, Japan
Masato Hoshi, Department of Biochemical and Analytical Science, Fujita Health University Graduate School of Health Sciences, Toyoake 470-1192, Japan
Akihiro Hirata, Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu 501-1193, Japan
Tatsuya Ando, Hiroyuki Tezuka, Department of Cellular Function Analysis, Research Promotion and Support Headquarters, Fujita Health University Graduate School of Health Sciences, Toyoake 470-1192, Japan
Takayuki Hattori, Faculty of Medical Technology, Gifu University of Medical Science, Gifu 501-3892, Japan
Hiroyuki Tomita, Akira Hara, Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1193, Japan
Author contributions: Hoshi M, Hara A, and Saito K planned the studies; Tashita C, Hoshi M, Hirata A, Tezuka H, Hattori T, Yamamoto Y, and Tomita H performed the experiments; Tashita C and Hoshi M had responsibility for all data integrity and data analysis; Tashita C, Hoshi M, Hirata A, Tezuka H, Nakamoto K, Ando T, Hattori T, Yamamoto Y, Tomita H, Hara A, and Saito K discussed the results; Tashita C, Hoshi M, and Tezuka H wrote the manuscript; Hara A and Saito K conducted the research; Saito K had primary responsibility for the final content; all authors reviewed and approved the manuscript.
Supported by Grants-in-Aids for Young Scientists (B) from the Japan Society for the Promotion of Science, No. 17K15785; and Fujita Health University Grant (2018).
Institutional review board statement: This research was approved by the Ethics Committee of Fujita Health University.
Institutional animal care and use committee statement: This research was approved by Animal Experimental Ethical Inspection of Fujita Health University, NO. APU19040.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Masato Hoshi, PhD, Assistant Professor, Department of Biochemical and Analytical Science, Fujita Health University Graduate School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan. firstname.lastname@example.org
Received: November 5, 2019
Peer-review started: November 5, 2019
First decision: December 23, 2019
Revised: January 6, 2020
Accepted: February 21, 2020
Article in press: February 21, 2020
Published online: March 7, 2020