Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma
Ezekiel Maloney, Ravneet Vohra, Joshua Park, Donghoon Lee, Department of Radiology, University of Washington, Seattle, WA 98195, United States
Yak-Nam Wang, Applied Physics Laboratory, University of Washington, Seattle, WA 98195, United States
Helena Son, Stella Whang, Tatiana Khokhlova, Kayla Gravelle, Stephanie Totten, Division of Gastroenterology, University of Washington, Seattle 98195, WA, United States
Joo Ha Hwang, Division of Gastroenterology & Hepatology, Stanford University School of Medicine, Redwood City, CA 94063, United States
Author contributions: Maloney E, Wang YN, Vorha R, Son H, Whang S, Khokhlova T, Park J, Gravelle K, and Lee D performed the majority of experiments; Maloney E, Wang YN, Vorha R, and Park J performed the majority of data analysis; Maloney E, Wang YN, and Lee D performed the majority of data interpretation; S Totten assisted Wang YN, S Whang, H Son and K Gravelle in treatment and care of the involved animals, as well as tissue processing/testing; Lee D and Hwang JH designed and coordinated the research; Maloney E wrote the initial draft of the manuscript; Maloney E and Wang YN created the figures; all authors contributed to manuscript content over multiple subsequent rounds of internal editing and revision prior to submission; all authors agreed upon the final content of the manuscript.
Supported by National Institutes of Health, National Cancer Institute, No. R01 CA188654 and No. R01 CA154451.
Institutional animal care and use committee statement: All animal experiments were conducted in accordance with policies of the NIH Guide for the Care and Use of Laboratory Animals and the Institutional Animal Care and Use Committee (IACUC) of the University of Washington. Specific protocols used in this study were approved by the University of Washington IACUC (approved protocols are: “4210-01: MR Methods for Small Animal Imaging” and “4242-05: Enhanced chemotherapeutic drug delivery by High Intensity Focused Ultrasound”).
Conflict-of-interest statement: All other authors have nothing to disclose.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Donghoon Lee, PhD, Research Professor, Department of Radiology, University of Washington, SLU C256, 850 Republican Street, Seattle, WA 98109, United States. firstname.lastname@example.org
Received: November 17, 2019
Peer-review started: November 17, 2019
First decision: December 23, 2019
Revised: January 12, 2020
Accepted: February 15, 2020
Article in press: February 15, 2020
Published online: March 7, 2020