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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2020; 26(6): 627-644
Published online Feb 14, 2020. doi: 10.3748/wjg.v26.i6.627
Published online Feb 14, 2020. doi: 10.3748/wjg.v26.i6.627
MiR-19a-3p regulates the Forkhead box F2-mediated Wnt/β-catenin signaling pathway and affects the biological functions of colorectal cancer cells
Fu-Bing Yu, Juan Sheng, Jing-Hua Liu, Department of Gastroenterology, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China
Jia-Man Yu, Department of Clinical Laboratory, The Geriatrics Hospital of Yunnan Province, Kunming 650011, Yunnan Province, China
Xiang-Xin Qin, Bo Mou, Department of Clinical Nutrition, The Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China
Author contributions: Sheng J designed the research; Yu FB performed the research; Yu JM and Mou B analyzed the data; Liu JH and Qin XX wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Fourth Affiliated Hospital of Kunming Medical University Ethics Committee.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interest.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bo Mou, MD, Chief Physician, Department of Clinical Nutrition, The Fourth Affiliated Hospital of Kunming Medical University, No.176, Qingnian Road, Wuhua District, Kunming 650021, Yunnan Province, China. md3ue0mc@163.com
Received: October 10, 2019
Peer-review started: October 10, 2019
First decision: November 27, 2019
Revised: December 3, 2019
Accepted: December 22, 2019
Article in press: December 22, 2019
Published online: February 14, 2020
Peer-review started: October 10, 2019
First decision: November 27, 2019
Revised: December 3, 2019
Accepted: December 22, 2019
Article in press: December 22, 2019
Published online: February 14, 2020
Core Tip
Core tip: Colorectal cancer (CRC) has a high rate of mortality, and patients with this disease often miss the optimal treatment period due to the lack of clinical symptoms of early CRC, which affects their prognosis. At present, CRC is extremely difficult to prevent and treat. Therefore, this study investigated the changes in biological functions of CRC cells from the perspective of the CRC mechanism, with the goal of evaluating the effects of microRNA miR-19a-3p-mediated regulation of the Forkhead box F2-mediated Wnt/β-catenin signaling pathway on the biological functions of CRC cells.