Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Jie Yang, Ya-han Zhang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Ji-Bin Liu, Qiang Lu
Jie Yang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Qiang Lu, Department of Medical Ultrasound, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Ya-han Zhang, Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Ji-Bin Liu, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, United States
Author contributions: Yang J and Lu Q designed the research; Yang J, Li JW, Shi YY, Luo Y and Lu Q performed the research; Zhang YH contributed to pathologic analysis studies; Yang J, Li JW, Shi YY, Huang JY and Lu Q collected the data. Yang J and Lu Q drafted the manuscript and reviewed the literature; Luo Y and Liu JB revised the manuscript; All authors approve the final version of the submitted manuscript and agree to ensure that any questions related to the work are appropriately resolved.
Supported by National Natural Science Foundation of China, No. 81571697; and The Science and Technology Department of Sichuan Province, No. 2017SZ0003 and No. 2018FZ0044.
Institutional review board statement: This study was reviewed and approved by the review board of West China Hospital of Sichuan University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors have no financial relationships to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Qiang Lu, MD, Professor, Department of Medical Ultrasound, West China Hospital of Sichuan University, No. 37 Guoxue Xiang, Chengdu 610041, Sichuan Province, China. luqiang@scu.edu.cn
Received: August 6, 2020
Peer-review started: August 6, 2020
First decision: October 18, 2020
Revised: October 31, 2020
Accepted: November 9, 2020
Article in press: November 9, 2020
Published online: December 14, 2020
